SajStorLab

Insulin-like human growth factor I is a protein from the family of insulin-like growth factors, a hormone with a pleiotropic effect, which is involved in the growth processes of cell proliferation and differentiation, promotes cell survival, maintains their functions, and has anabolic effects.

Interleukin 4 is a pleiotropic cytokine that regulates the cellular and humoral immune response and is involved in the processes of proliferation, differentiation, and activation of cells of various types. IL-4 is expressed by activated T lymphocytes, mast cells, dendritic cells, NKT cells, basophils, eosinophils. The epithelium and tumor cells are sources of IL-4 in tissues.

Human Serum Albumin (HSA) is the main human plasma protein and has many physiological properties due to its unique structure.

Vascular Endothelial Growth Factor is one of the key regulators of angiogenesis. The most important role in the human body is played by a protein of the VEGF family called VEGF-A. VEGF-A is a 45 kDa glycoprotein homodimer and plays a key role in chemotaxis and angioblast differentiation, endotheliocyte (EC) proliferation, vasculogenesis, and vascular remodeling. As a result of alternative splicing or proteolytic cleavage, 4 main isoforms of VEGF-A are formed, consisting of 121, 165, 189, or 206 amino acid residues.

Green fluorescent protein (GFP) isolated from the jellyfish species Aequorea Victoria, consists of 238 amino acids with a molecular weight of about 27 kDa. GFP is characterized by two absorption peaks in blue light at 395 nm (major) and 475 nm (minor) and a fluorescence peak at 498 nm in the green range. At present, the gene for this protein and proteins derived from it, glowing with different colors, is used as a luminous marker in cell and molecular biology to study protein expression in cells and living organisms in vivo. GFP also allows purification of recombinant proteins, where GFP or its derivatives are used as an affinity label.

Thrombopoietin is a glycoprotein hormone synthesized mainly in the liver, the main physiological regulator of platelet production. Participates in the development of precursors of other blood cells. TPO and other TPO receptor agonists are promising therapeutic agents.

Interleukin 3 is a cytokine, a multipotent colony-stimulating hematopoietic factor, produced mainly by activated T-lymphocytes. The main function of IL-3 is participation in the differentiation and proliferation of myeloid precursor cells. IL-3 is involved in the pathogenesis of a number of diseases, including hematological tumors. IL-3 is a therapeutic agent in the treatment of conditions associated with insufficient hematopoietic function of the bone marrow.

Erythropoietin (EPO) is a cytokine (glycoprotein) that stimulates erythropoiesis.

Tumor Necrosis Factor α, TNFα is a pleiotropic pro-inflammatory cytokine produced by monocytes, macrophages, fibroblasts, and astrocytes. One of the proteins of the acute phase of inflammation. It has antitumor activity. TNFα is involved in the pathogenesis of a number of diseases.

Stem cell factor is a growth factor produced mainly by fibroblasts and endothelial cells. The cytokine SCF plays an important role in the survival and proliferation of hematopoietic cells, melanocytes and germ cells, their migration and differentiation.

Leukemiainhibitoryfactor (LIF), also known as differentiation stimulating factor (D factor) or melanoma-derived LPL inhibitor (MLPLI). LIF is involved in the regulation of hematopoiesis, bone metabolism, neurodevelopment, and inflammation.

Fibroblast growth factor-2 is a member of the fibroblast growth factor family. It has mitogenic activity against target cells, is a neurotrophic factor, participates in the regulation of angiogenesis, individual development, tissue regeneration, reproduction and pathogenesis of a number of diseases, including malignant tumors.