SajStorLab

Interleukin 3 is a cytokine, a multipotent colony-stimulating hematopoietic factor, produced mainly by activated T-lymphocytes. The main function of IL-3 is participation in the differentiation and proliferation of myeloid precursor cells. IL-3 is involved in the pathogenesis of a number of diseases, including hematological tumors. IL-3 is a therapeutic agent in the treatment of conditions associated with insufficient hematopoietic function of the bone marrow.

Human hepatocyte growth factor - participates in the processes of morphogenesis and regeneration, stimulation of the survival of hepatocytes, tubular cells of the kidneys, neurons.

Interleukin 2 is a cytokine that has pleiotropic properties and regulates several functional responses of target cells. It induces T cell proliferation (acting as a growth factor) and effector T cell synthesis of cytokines, thus providing an effector response. IL-2 is also a key factor in the development, expansion and maintenance of regulatory T cells, which plays an important role in balancing and regulating the immune response and preventing autoimmune diseases. Interleukin 2 is also capable of activating a number of other cells (B-lymphocytes, NK cells, neutrophils), triggering the processes of autivation and expression of receptor genes in them, the synthesis of effector molecules, and phosphorylation pathways for many intracellular proteins.

Epidermal growth factor is a polypeptide that stimulates the differentiation and growth of epithelial cells.

Nojin is a protein involved in the development of various tissues, including bone, muscle and nerve. It is an antagonist of bone morphogenetic proteins (MBPs). Noggin has been implicated in a number of pathological conditions.

Insulin-like human growth factor I is a protein from the family of insulin-like growth factors, a hormone with a pleiotropic effect, which is involved in the growth processes of cell proliferation and differentiation, promotes cell survival, maintains their functions, and has anabolic effects.

Stem cell factor is a growth factor produced mainly by fibroblasts and endothelial cells. The cytokine SCF plays an important role in the survival and proliferation of hematopoietic cells, melanocytes and germ cells, their migration and differentiation.

Interleukin-6 is a cytokine that is secreted in response to infection or tissue damage and induces the production of proteins of the acute phase of inflammation, stimulates hematopoiesis and the immune response.

Green fluorescent protein (GFP) isolated from the jellyfish species Aequorea Victoria, consists of 238 amino acids with a molecular weight of about 27 kDa. GFP is characterized by two absorption peaks in blue light at 395 nm (major) and 475 nm (minor) and a fluorescence peak at 498 nm in the green range. At present, the gene for this protein and proteins derived from it, glowing with different colors, is used as a luminous marker in cell and molecular biology to study protein expression in cells and living organisms in vivo. GFP also allows purification of recombinant proteins, where GFP or its derivatives are used as an affinity label.

Tumor Necrosis Factor α, TNFα is a pleiotropic pro-inflammatory cytokine produced by monocytes, macrophages, fibroblasts, and astrocytes. One of the proteins of the acute phase of inflammation. It has antitumor activity. TNFα is involved in the pathogenesis of a number of diseases.

Vascular Endothelial Growth Factor is one of the key regulators of angiogenesis. The most important role in the human body is played by a protein of the VEGF family called VEGF-A. VEGF-A is a 45 kDa glycoprotein homodimer and plays a key role in chemotaxis and angioblast differentiation, endotheliocyte (EC) proliferation, vasculogenesis, and vascular remodeling. As a result of alternative splicing or proteolytic cleavage, 4 main isoforms of VEGF-A are formed, consisting of 121, 165, 189, or 206 amino acid residues.

Leukemiainhibitoryfactor (LIF), also known as differentiation stimulating factor (D factor) or melanoma-derived LPL inhibitor (MLPLI). LIF is involved in the regulation of hematopoiesis, bone metabolism, neurodevelopment, and inflammation.