SajStorLab

Stem cell factor is a growth factor produced mainly by fibroblasts and endothelial cells. The cytokine SCF plays an important role in the survival and proliferation of hematopoietic cells, melanocytes and germ cells, their migration and differentiation.

Tumor Necrosis Factor α, TNFα is a pleiotropic pro-inflammatory cytokine produced by monocytes, macrophages, fibroblasts, and astrocytes. One of the proteins of the acute phase of inflammation. It has antitumor activity. TNFα is involved in the pathogenesis of a number of diseases.

Thrombopoietin is a glycoprotein hormone synthesized mainly in the liver, the main physiological regulator of platelet production. Participates in the development of precursors of other blood cells. TPO and other TPO receptor agonists are promising therapeutic agents.

Placental Growth Factor, PlGF is a protein from the family of vascular endothelial growth factors (VEGF), synthesized mainly by trophoblast cells, stimulating the development of placental vessels and proliferation of trophoblast cells.

Green fluorescent protein (GFP) isolated from the jellyfish species Aequorea Victoria, consists of 238 amino acids with a molecular weight of about 27 kDa. GFP is characterized by two absorption peaks in blue light at 395 nm (major) and 475 nm (minor) and a fluorescence peak at 498 nm in the green range. At present, the gene for this protein and proteins derived from it, glowing with different colors, is used as a luminous marker in cell and molecular biology to study protein expression in cells and living organisms in vivo. GFP also allows purification of recombinant proteins, where GFP or its derivatives are used as an affinity label.

Vascular Endothelial Growth Factor is one of the key regulators of angiogenesis. The most important role in the human body is played by a protein of the VEGF family called VEGF-A. VEGF-A is a 45 kDa glycoprotein homodimer and plays a key role in chemotaxis and angioblast differentiation, endotheliocyte (EC) proliferation, vasculogenesis, and vascular remodeling. As a result of alternative splicing or proteolytic cleavage, 4 main isoforms of VEGF-A are formed, consisting of 121, 165, 189, or 206 amino acid residues.

Nojin is a protein involved in the development of various tissues, including bone, muscle and nerve. It is an antagonist of bone morphogenetic proteins (MBPs). Noggin has been implicated in a number of pathological conditions.

Vascular Endothelial Growth Factor is one of the key regulators of angiogenesis. The most important role in the human body is played by a protein of the VEGF family called VEGF-A. VEGF-A is a 45 kDa glycoprotein homodimer and plays a key role in chemotaxis and angioblast differentiation, endotheliocyte (EC) proliferation, vasculogenesis, and vascular remodeling. As a result of alternative splicing or proteolytic cleavage, 4 main isoforms of VEGF-A are formed, consisting of 121, 165, 189, or 206 amino acid residues.

Human Serum Albumin (HSA) is the main human plasma protein and has many physiological properties due to its unique structure.

Interleukin-6 is a cytokine that is secreted in response to infection or tissue damage and induces the production of proteins of the acute phase of inflammation, stimulates hematopoiesis and the immune response.

Interleukin 2 is a cytokine that has pleiotropic properties and regulates several functional responses of target cells. It induces T cell proliferation (acting as a growth factor) and effector T cell synthesis of cytokines, thus providing an effector response. IL-2 is also a key factor in the development, expansion and maintenance of regulatory T cells, which plays an important role in balancing and regulating the immune response and preventing autoimmune diseases. Interleukin 2 is also capable of activating a number of other cells (B-lymphocytes, NK cells, neutrophils), triggering the processes of autivation and expression of receptor genes in them, the synthesis of effector molecules, and phosphorylation pathways for many intracellular proteins.

Interleukin 3 is a cytokine, a multipotent colony-stimulating hematopoietic factor, produced mainly by activated T-lymphocytes. The main function of IL-3 is participation in the differentiation and proliferation of myeloid precursor cells. IL-3 is involved in the pathogenesis of a number of diseases, including hematological tumors. IL-3 is a therapeutic agent in the treatment of conditions associated with insufficient hematopoietic function of the bone marrow.